| Identification | More | [Name]
Dolasteron | [CAS]
40828-46-4 | [Synonyms]
DOLASETRON
(+-)-2-(p-(2-thenoyl)phenyl)propionicacid
alpha-methyl-4-(2-thienylcarbonyl)-benzeneaceticaci
alpha-methyl-4-(2-thienylcarbonyl)benzeneaceticacid
maldocil
p-(2-thenoyl)-hydratropicaci
p-(2-thenoyl)hydratropicacid
r25061
a-Methyl-4-(2-thienylcarbonyl)benzeneacetic Acid
Masterfen
Srendam
Sulprotin
Suprocil
Suprol
Sutoprofen
Topalgic
DOLASETRON(FREE BASE)
Benzeneacetic acid, a-methyl-4-(2-thienylcarbonyl)-(9CI)
NSC 303611
Profenal | [EINECS(EC#)]
255-096-9 | [Molecular Formula]
C14H12O3S | [MDL Number]
MFCD00079572 | [Molecular Weight]
260.308 | [MOL File]
40828-46-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Light-Brown | [Melting point ]
278°C | [Boiling point ]
373.57°C (rough estimate) | [density ]
1.2959 (rough estimate) | [refractive index ]
1.5050 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [form ]
Powder | [pka]
3.91(at 25℃) | [color ]
White to off-white | [Water Solubility ]
soluble | [Usage]
Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic. | [CAS DataBase Reference]
40828-46-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [RIDADR ]
3249 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2934990002 | [Toxicity]
LD50 (7 days post-drug) in mice, rats, guinea pigs, dogs (mg/kg): 590, 353, 280, 160 orally (Niemegeers) |
| Hazard Information | Back Directory | [Description]
Suprofen is an arylpropionic acid analgesic/antiinflammatory agent with close
structural resemblance to ketoprofen. It is more potent in many assays than
indomethacin and ketoprofen and appears better tolerated. | [Chemical Properties]
Off-White to Light-Brown | [Originator]
Janssen (Belgium) | [Uses]
Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic. | [Uses]
Prostaglandin biosynthesis inhibitor. Analgesic | [Definition]
ChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group. | [Brand name]
Profenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL. | [Veterinary Drugs and Treatments]
Suprofen is a non-steroidal anti-inflammatory agent similar to
flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids
that inhibit the cyclo-oxygenase enzymes responsible for conversion
of arachadonic acid from cell membranes into various prostaglandins.
These prostaglandins mediate certain aspects of ocular
inflammation including disruption of the blood-aqueous barrier,
uveal vasodilation, increases in intraocular pressure, and leakage of
white blood cells and protein from uveal vessels into the aqueous
humor. Prostaglandins cause iris sphincter constriction (miosis)
independent of cholinergic mechanisms. Suprofen can inhibit this
intraocular miosis and may also be useful in the management of
uveal inflammation (usually in addition to topical steroids). | [storage]
Store at -20°C |
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