| Identification | More | [Name]
Ginsenoside Rb1 | [CAS]
41753-43-9 | [Synonyms]
(3beta,12beta)-20-[(6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside
GINSENOSIDE GINSENOSIDE-RB1
GINSENOSIDE RB1
GINSENOSIDE RBL
GYPENOSIDE
SANCHINOSIDE E1
(3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-beta-d-glucopyranosid
arasaponine1
glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-
gynosaponinc
gypenosideiii
panaxsaponine
pseudoginsenosided
2-O-beta-glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside
Ginsenoside Rb1 std.
ginsenoside-rb1from panax quinquefolium (american ginseng)root
Ginsenoside Rb1 (CAS# 41753-43-9)
GinsenosideRB1,SanchinosideE1
GINSENOSIDE Rb1 hplc
Gensenoside Rb1 | [EINECS(EC#)]
255-532-8 | [Molecular Formula]
C54H92O23 | [MDL Number]
MFCD00133367 | [Molecular Weight]
1109.29 | [MOL File]
41753-43-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
197.5°C | [Boiling point ]
766.35°C (rough estimate) | [density ]
1.0971 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellow | [form ]
neat | [pka]
12.85±0.70(Predicted) | [color ]
Off-White to Pale Beige | [Detection Methods]
NMR,HPLC | [Stability:]
Hygroscopic | [InChIKey]
GZYPWOGIYAIIPV-VOKNSFSUNA-N | [LogP]
2.900 (est) | [CAS DataBase Reference]
41753-43-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
LZ5856000
| [HS Code ]
29389090 | [Toxicity]
oms-rat-ipr 50 mg/kg CPBTAL 24,2400,76 |
| Hazard Information | Back Directory | [Description]
Ginsenoside Rb1 (41753-43-9), a glycosylated PPD type ginsenoside with two sugars linked to C-3 and two sugars linked to C-20, is the major active constituent of American ginseng. Studies have demonstrated the anti-aging effects of ginsenoside Rb1 at both animal and cell levels. 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (20GPPD) is the major ingredient of ginsenoside Rb1, which has been shown to increase HAS2 expression by phosphorylating ERK and AKT signaling in human keratinocytes in a dose-dependent manner in vitro.
| [Uses]
A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects. | [Uses]
Reference standard in the analysis of herbal medicinal products. | [Definition]
ChEBI: Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd. | [benefits]
Ginsenoside Rb1 (G-Rb1) is a tetracyclic triterpenoid mainly obtained from the roots or stems of Panax notoginseng and ginseng by extraction and purification. It is one of the main bioactive compounds of ginseng with minimal toxicity and neurotrophic and neuroprotective effects on brain injury. G-Rb1 promotes hippocampal nerve regeneration, enhances learning and memory, and has anti-aging and anti-fatigue effects. In addition, it activates antioxidants, stimulates the immune system, has anti-apoptotic activity, and maintains cell adenosine triphosphate (ATP) levels[1].
| [General Description]
Ginsenoside Rb1 (41753-43-9) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS. | [Biochem/physiol Actions]
Triterpene saponin found in ginseng. | [Safety Profile]
Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke and irritating fumes. | [target]
p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor | [References]
[1] Shan Wen. “Ginsenoside Rb1 improves energy metabolism after spinal cord injury.” Neural Regeneration Research 18 6 (2023): 1332–1338.
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