| Identification | More | [Name]
Sodium ketoisocaproate | [CAS]
4502-00-5 | [Synonyms]
2-KETOISOCAPROIC ACID SODIUM SALT
2-KETOISOHEXANOIC ACID SODIUM SALT
4-Methyl-2-oxopentanoic acid monosodium salt
4-METHYL-2-OXOPENTANOIC ACID SODIUM SALT
4-METHYL-2-OXOVALERIC ACID SODIUM SALT
A-KETOISOCAPROIC ACID, SODIUM SALT
ALPHA-KETOISOCAPROIC ACID SODIUM SALT
KETOLEUCINE SODIUM SALT
SODIUM 4-METHYL-2-OXOVALERATE
SODIUM ALPHA-KETOISOCAPRATE
Sodium ketoisocaproate
A-ketoisocaproic acid sodium
4-METHYL-2-OXOPENTANOIC ACID, SODIUM SAL T,98%
SODIUM ALPHA-KETOISOCAPROATE
Sodium4-Methyl-2-oxopentanoate
4-methyl-2-oxo-pentanoate, sodium salt
alpha-Ketoisocaproic Acid, Sodium Salt-isopropyl-D7
Pentanoic acid, 4-methyl-2-oxo-, sodium salt
α-Ketoisocaproic Acid, Sodium Salt-isopropyl-D7
α-Ketoisocaproic Acid, Sodium Salt-1-13C | [EINECS(EC#)]
224-816-3 | [Molecular Formula]
C6H9NaO3 | [MDL Number]
MFCD00064193 | [Molecular Weight]
152.12 | [MOL File]
4502-00-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
275 °C (dec.)(lit.) | [storage temp. ]
2-8°C
| [solubility ]
Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Odor]
at 100.00 %. butyric valeric buttery | [biological source]
synthetic | [Odor Type]
buttery | [JECFA Number]
633.1 | [BRN ]
4239297 | [Stability:]
Hygroscopic | [LogP]
0.17 | [CAS DataBase Reference]
4502-00-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
3
|
| Hazard Information | Back Directory | [Occurrence]
Reported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese. | [Uses]
Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method. | [Uses]
4-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine. | [Biochem/physiol Actions]
α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria. |
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