| Identification | More | [Name]
Chrysin | [CAS]
480-40-0 | [Synonyms]
5,7-dihydroxy-2-phenyl-4h-benzo[b]pyran-4-one
5,7-DIHYDROXY-2-PHENYL-CHROMEN-4-ONE
5,7-DIHYDROXYFLAVONE
AKOS NCG1-0026
CHRYSIN
CHRYSINE
LABOTEST-BB LT00440772
5,7-dihydroxy-2-phenyl-4h-1-benzopyran-4-on
5,7-dihydroxy-2-phenyl-4h-1-benzopyran-4-one
5,7-dihydroxy-flavon
Chrysin, 99+%
CHRYSIN(RG)
5,7-DIHYDROXYFLAVONE(CHRYSIN)
Chrysin 5,7-
Chrysin 99.0%min
CHRYSIN (5,7-HYDROXYFLAVONE)
Chrysin Extract
4H-1-Benzopyran-4-one,5,7-dihydroxy-2-phenyl-
Chrysidenon 1438 | [EINECS(EC#)]
207-549-7 | [Molecular Formula]
C17H14O7 | [MDL Number]
MFCD00006834 | [Molecular Weight]
330.29 | [MOL File]
480-40-0.mol |
| Chemical Properties | Back Directory | [Appearance]
beige powder | [Melting point ]
284-286 °C(lit.)
| [Boiling point ]
357.45°C (rough estimate) | [density ]
1.2693 (rough estimate) | [refractive index ]
1.4872 (estimate) | [storage temp. ]
0-6°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
6.50±0.40(Predicted) | [color ]
Yellow | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Merck ]
14,2256 | [BRN ]
233276 | [InChIKey]
RTIXKCRFFJGDFG-UHFFFAOYSA-N | [LogP]
3.520 | [CAS DataBase Reference]
480-40-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
LK8329050
| [F ]
10 | [HazardClass ]
IRRITANT | [HS Code ]
29329900 |
| Hazard Information | Back Directory | [Description]
Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells.1,2 Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 μM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo.3 In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.4 | [Chemical Properties]
beige powder | [Physical properties]
beige powder | [Uses]
Chrysin is a flavanoid with anti-inflammatory effect and potential protective effects against cancer and cardiovascular disease. Studies show that Chrysin is central benzodiazepine receptor ligand wit
h possible anxiolytic effects. Chrysin was initially believed to have aromatase inhibitor but recent in vivo studies have disproved that. | [Uses]
diuretic | [Definition]
ChEBI: A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. | [Biological Functions]
Chrysin, also referred to as 5,7-dihydroxyflavone, is a naturally occurring antioxidant flavonoi. It holds immense potential for diverse applications and is being investigated as a potential therapeutic agent for various conditions and diseases. Research on chrysin has revealed its antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties, along with its ability to modulate the activity of specific enzymes, hormones, and neurotransmitters. Its therapeutic potential extends to areas like oncology, diabetes, and neurological disorders. Although the precise mechanism of action of chrysin is not yet fully comprehended, research suggests its ability to modulate the activity of enzymes, hormones, and neurotransmitters. For instance, it has shown the potential to influence the activity of aromatase, an enzyme involved in estrogen production. Moreover, chrysin has exhibited inhibitory effects on cancer cell growth and inflammation by influencing the activity of specific enzymes and hormones. It was discovered that Chrysin inhibits HIF-1α (hypoxia-inducible factor-1α) and induces apoptosis. | [target]
NOS | COX | TNF-α | PGE | IL Receptor | PI3K | Akt | Caspase | NF-kB | TGF-β/Smad | [Source]
The main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata. |
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