| Identification | Back Directory | [Name]
MILBEMECTIN A3 | [CAS]
51596-10-2 | [Synonyms]
milbemycin
milbemycinb-2
milbemycin A3
Milbemycin α1
Milbemycin α1
MILBEMECTIN A3
milbemectine a3
Antibiotic B-41A3
Milbemycin EP Imp B
Milbemycin oxime A3
Milbemite Impurity 1
Milbemycin EP Impurity B
Milbemycin Oxime EP Impurity B
B 41A3, MilbeMycin alpha1, MilbeMectin
(+)-Chloropseudoephedrine (hydrochloride)
Milbemycin Impurity 2(Milbemycin EP Impurity B)
(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B
(25R)-25-Methyl-5β-hydroxy-5-demethoxy-28-O,6β-cyclomilbemycin B
Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-methyl-, (6R,25R)- | [Molecular Formula]
C31H44O7 | [MDL Number]
MFCD04972569 | [MOL File]
51596-10-2.mol | [Molecular Weight]
528.69 |
| Chemical Properties | Back Directory | [Melting point ]
212-215°; mp 192-194° | [alpha ]
D20 +106° (c = 0.25 in acetone) (Aoki); D20 +106° (acetone) (Hirama) | [Boiling point ]
725.5±60.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
0-6°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A solid | [pka]
12.46±0.70(Predicted) | [EPA Substance Registry System]
Milbemycin A3 (51596-10-2) |
| Hazard Information | Back Directory | [Description]
Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin A3 is used as a nematocide and insecticide. The acaricidal and nematocidal activity of a mixture of milbemycin A3 and milbemycin A4 against adult spider mites, spider mite eggs, and C. elegans are reported at IC50 values of 5.3, 41.1, and 9.5 μg/ml. | [Uses]
Milbemycin A3 is widely used as a pesticides in agriculture. Milbemycin A3 (Milbemycin EP Impurity B) is an antibiotic with acaricidal activity. | [Uses]
Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A3 is a major member of a group of analogues containing a 25-methyl substituent. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels. | [Definition]
ChEBI: Milbemycin A3 is a milbemycin. |
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