| Identification | Back Directory | [Name]
MilbeMycin A3 OxiMe | [CAS]
114177-14-9 | [Synonyms]
MilbeMycin A3 OxiMe
Milbemite Impurity 2
5-OxoMilbeMycin A3 oxiMe
5-ketomilbemycin A3 5-oxime
Milbemycin Impurity 10(Milbemycin A3 Oxime)
Milbemycin B, 5-demethoxy-28-deoxy-6,28-epoxy-5-(hydroxyimino)-25-methyl-, (6R,25R)- | [Molecular Formula]
C31H43NO7 | [MDL Number]
MFCD21363714 | [MOL File]
114177-14-9.mol | [Molecular Weight]
541.68 |
| Hazard Information | Back Directory | [Description]
Milbemycin A3 oxime is an anthelmintic, a derivative of milbemycin A3 , and a component of milbemycin oxide . It reduces the number of microfilariae of the heartworm D. immitis in the blood of naturally infested dogs by 85.2% when administered at a dose of 0.05 mg/kg. Formulations containing milbemycin A3 oxime, in combination with milbemycin A4 oxime, have been used in the treatment of parasitic infections in dogs. | [Uses]
Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking. | [Uses]
Milbemycin A3 oxime is the minor component of the anti-parasitic product milbemycin oxime. |
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