ChemicalBook--->CAS DataBase List--->519055-62-0

519055-62-0

519055-62-0 Structure

519055-62-0 Structure
IdentificationBack Directory
[Name]

Tasisulam
[CAS]

519055-62-0
[Synonyms]

CS-519
TS81557
Tssolan
Ly573636
Ly-573636
tasisulam
LY573636-sodium
Tasisulam, >=98%
Tasisulam(Ly-573636
Tasisulam USP/EP/BP
LY573636 (TasisulaM)
TASISULAMUM TASISULAM
LY573636-SODIUM; BENZAMIDE
LY573636-SODIUM; BENZAMIDE;LY573636
N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide
N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide
Benzamide, N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichloro-
Tasisulam N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide
N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide LY573636 Tasisulam
[Molecular Formula]

C11H6BrCl2NO3S2
[MDL Number]

MFCD11973637
[MOL File]

519055-62-0.mol
[Molecular Weight]

415.11
Chemical PropertiesBack Directory
[density ]

1.812
[storage temp. ]

Store at -20° C
[solubility ]

DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.2 mg/ml
[form ]

A crystalline solid
[pka]

3.45±0.10(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

The sodium salt of Tasisulam has potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS).
[Biological Activity]

Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) th at bridges RNA binding motif protein 39 (RBM39; CAPERαHCC1) and DCAF15 for interactionthereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC50 = 6.5 μM)but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM.
Spectrum DetailBack Directory
[Spectrum Detail]

Tasisulam(519055-62-0)1HNMR
519055-62-0 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: Shenzhen Excellent Biotech Co., Ltd.
Tel: 13480692018
Website: www.chemicalbook.com/ShowSupplierProductsList1588779/0.htm
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581 , +undefined18051384581
Website: https://www.chemhifuture.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054 , 13417589054
Website: www.chemicalbook.com/ShowSupplierProductsList1962465/0.htm
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Henan Fengda Chemical Co., Ltd
Tel: +86-371-86557731 +86-13613820652 , +86-13613820652
Website: http://www.fdachem.com
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel: +8613817748580 , +8613817748580
Website: www.kean-chem.com
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghaizehan biopharma technology co., Ltd.  Gold
Tel: 021-61350663 13052117465
Website: http://www.zehanbiopharma.com
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Website: http://www.jkchemical.com
Tags:519055-62-0 Related Product Information
98-10-2 154350-29-5 98-18-0 63-74-1 3144-09-0 70-55-3 1403254-99-8 1282512-48-4 254964-60-8 315183-21-2 1009820-21-6 936563-96-1 783355-60-2 1421373-65-0 763113-22-0 53595-65-6

This site uses cookies
This website uses cookies and similar technologies to store and retrieve information about your use of this website. This information helps us to provide, analyse and improve our services, which may include personalised content or advertising. We may share this information with Google and other third parties. This cookies are necessary for our website to work properly . By clicking "Continue" or continuing to browse our site you are agreeing to our and our partners use of cookies.
Accept