52026-48-9

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52026-48-9 Structure

Identification	Back Directory
[Name] HO-PEG5-CH2COOtBu
[CAS] 52026-48-9
[Synonyms] HO-PEG5-CH2COOH HO-PEG5-CH2COOtBu Hydroxy-PEG5-CH2COOH Hydroxy-PEG5-acetic acid
[Molecular Formula] C12H24O8
[MDL Number] MFCD31656910
[MOL File] 52026-48-9.mol
[Molecular Weight] 296.31

Hazard Information	Back Directory
[Biological Activity] HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References] [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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