| Identification | More | [Name]
4-Aminobenzohydrazide | [CAS]
5351-17-7 | [Synonyms]
4-AMINOBENZHYDRAZIDE
4-AMINOBENZOHYDRAZIDE
4-AMINO-BENZOIC ACID HYDRAZIDE
4-AMINOBENZOIC HYDRAZIDE
4-AMINOBENZOYLHYDRAZIDE
LABOTEST-BB LT00010042
MYELOPEROXIDASE INHIBITOR-I
P-AMINOBENZHYDRAZIDE
P-AMINOBENZOHYDRAZIDE
P-AMINOBENZOIC ACID HYDRAZIDE
P-AMINOBENZOYL HYDRAZIDE
TIMTEC-BB SBB007555
4-amino-benzoicacihydrazide
4-Aminobenzoylhydrazine
Amben hydrazide
ambenhydrazide
aminostimil
Benzoic acid, p-amino-, hydrazide
p-Amino benzoyl hydrazine
p-Aminobenzoic hydrazide | [EINECS(EC#)]
226-324-4 | [Molecular Formula]
C7H9N3O | [MDL Number]
MFCD00007606 | [Molecular Weight]
151.17 | [MOL File]
5351-17-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White or beige crystals or powder | [Melting point ]
225-227 °C (lit.) | [Boiling point ]
273.17°C (rough estimate) | [density ]
1.2100 (rough estimate) | [refractive index ]
1.5860 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMF: 10 mg/ml; DMSO: 14 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | [form ]
Crystals or Powder | [pka]
13.05±0.10(Predicted) | [color ]
White or beige | [Water Solubility ]
Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible). | [BRN ]
639053 | [CAS DataBase Reference]
5351-17-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzoic acid, 4-amino-, hydrazide(5351-17-7) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DG2580000
| [HazardClass ]
IRRITANT | [HS Code ]
29280000 |
| Hazard Information | Back Directory | [Description]
4-Aminobenzoic acid hydrazide (4-ABAH) is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 0.3 μM).1 It reduces the production of hypochlorous acid (HOCl) induced by opsonized zymosan or phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in isolated human neutrophils with IC50 values of 16 and 2.2 μM, respectively. 4-ABAH inhibits PMA-induced formation of neutrophil extracellular traps (NETs) in the same cells.2 It reduces infarct volume and the severity of neurological deficits, as well as increases survival, in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg twice per day.3 | [Chemical Properties]
White or beige crystals or powder | [Uses]
4-Aminobenzhydrazide has an important role in the peroxidation activity of MPO. It is also used in enzyme preparations and in cell cultures. |
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