| Identification | Back Directory | [Name]
STEFFIMYCIN B | [CAS]
54526-94-2 | [Synonyms]
u40615
Nsc 204855
STEFFIMYCIN B
Steffimycin 4'-methyl ether
5,7-trihydroxy-3,9-dimethoxy-2-methyl-l)oxy)-4-dihydro-2
1,6,11(2h)-naphthacenetrione,4-((6-deoxy-2,4-di-o-methyl-alpha-l-mannopyranosy
4-(2-O,4-O-Dimethyl-α-L-rhamnopyranosyloxy)-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl-1,6,11(2H)-naphthacenetrione
4-[(2-O,4-O-Dimethyl-6-deoxy-α-L-mannopyranosyl)oxy]-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl-1,6,11(2H)-naphthacenetrione
1,6,11(2H)-Naphthacenetrione, 4-((6-deoxy-2,4-di-o-methyl-alpha-L-mannopyranosyl)oxy)-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl-
1,6,11(2H)-Naphthacenetrione, 4-[(6-deoxy-2,4-di-O-methyl-α-L-mannopyranosyl)oxy]-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl-, (2S,3S,4R)- | [Molecular Formula]
C29H32O13 | [MDL Number]
MFCD01713106 | [MOL File]
54526-94-2.mol | [Molecular Weight]
588.56 |
| Chemical Properties | Back Directory | [Boiling point ]
801.2±65.0 °C(Predicted) | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A lyophilisate | [pka]
5.09±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp., with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells. |
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