ChemicalBook--->CAS DataBase List--->6326-06-3

6326-06-3

6326-06-3 Structure

6326-06-3 Structure
IdentificationBack Directory
[Name]

AH 7614
[CAS]

6326-06-3
[Synonyms]

AH 7614
4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide
Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-
[Molecular Formula]

C20H17NO3S
[MDL Number]

MFCD00379273
[MOL File]

6326-06-3.mol
[Molecular Weight]

351.42
Chemical PropertiesBack Directory
[Melting point ]

196-197 °C(Solv: ethanol (64-17-5); 1,4-dioxane (123-91-1))
[Boiling point ]

505.9±60.0 °C(Predicted)
[density ]

1.37±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C (des.)
[solubility ]

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
[form ]

solid
[pka]

10.33±0.20(Predicted)
[color ]

Off-white
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Hazard InformationBack Directory
[Description]

AH-7614 (6326-06-3) is a selective antagonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pIC50s= 7.1 and 1.
[Uses]

AH 7614 is a sellective FFAR4 (free fatty acid receptor 4) antagonist which inhibits the intracellular calcium accumilation induced by linoleic acid or FFAR agonists.
[in vitro]

ah7614 (0.063, 0.25, and 1μm) blocked linoleic acid and gsk137647a-induced intracellular calcium increase in u2os osteosarcoma cells expressing the ffa4 receptor [1]. in addition, the increase of glucose-stimulated insulin secretion by gsk137647a (50 μm) was abolished in the presence of the selective ffa4 antagonist ah7614 (100 μm) in the min6 mouse insulinoma cell line. moreover, ah7614 (100 μm) blocked gsk137647a (100μm)-mediated a modest increase of glp-1 secretion in the ncih716 cells [1].
[target]

ffa4/gpr120
[storage]

Store at +4°C
[References]

1) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100
Spectrum DetailBack Directory
[Spectrum Detail]

AH 7614(6326-06-3)1HNMR
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