| Identification | More | [Name]
4-Chloro-3-nitroaniline | [CAS]
635-22-3 | [Synonyms]
1-AMINO-4-CHLORO-3-NITROBENZENE
3-NITRO-4-CHLOROANILINE
4-AMINO-1-CHLORO-2-NITROBENZENE
4-CHLORO-3-NITROANILINE
4-Chloro-3-nitrobenzenamine
5-Amino-2-chloronitrobenzene
4-chloro-3-nitro-anilin
4-chloro-3-nitro-benzenamin
Aniline, 4-chloro-3-nitro-
benzenamine,-chloro-3-nitro-
4-Chloro-3-Nitroaniline 3-Nitro-4-Chloroaniline
4-Chlor-3-nitroanilin
4-CHLORO-3-NITROANILINE 99+%
1-Amino-3-nitro-4-Chlorobenzene | [EINECS(EC#)]
211-231-3 | [Molecular Formula]
C6H5ClN2O2 | [MDL Number]
MFCD00007844 | [Molecular Weight]
172.57 | [MOL File]
635-22-3.mol |
| Chemical Properties | Back Directory | [Appearance]
ochre powder | [Melting point ]
99-101 °C (lit.) | [Boiling point ]
200°C (rough estimate) | [density ]
1.5610 (rough estimate) | [refractive index ]
1.5870 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
1.87±0.10(Predicted) | [color ]
White to Yellow to Orange | [BRN ]
1309394 | [InChI]
InChI=1S/C6H5ClN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2 | [InChIKey]
FOHHWGVAOVDVLP-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(Cl)C([N+]([O-])=O)=C1 | [Uses]
Intermediate in the manufacture of azo dyes,
pharmaceuticals, and other organic compounds. | [CAS DataBase Reference]
635-22-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 4-chloro-3-nitro-(635-22-3) | [EPA Substance Registry System]
635-22-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N,T | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2237 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
BX1750000
| [Hazard Note ]
Very Toxic | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214210 | [Safety Profile]
Poison by ingestion and
intraperitoneal routes. Experimental
reproductive effects. Skin and eye irritant.
When heated to decomposition it emits
toxic fumes of NOx and Cl-. | [Hazardous Substances Data]
635-22-3(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Hazard]
Toxic by ingestion and inhalation. | [Chemical Properties]
ochre powder | [Application]
Commercial 4-chloro-3-nitroaniline could be used as a starting material for 3-azido-4-chlorophenylisothiocyanate through a 5-step synthesis. In order to research the impact of the strain on the metabolite profile of plasma samples in rats, 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) was evaluated for 4 weeks. 4C3N administration led to extravascular hemolytic anemia with a few metabolome changes, which were strain-dependent [1-2].
| [References]
[1] H. Lamotte. “Synthesis of N‐(3‐azido‐4‐chlorophenyl)‐N′‐[3H‐methyl] thiourea, an efficient photoaffinity probe for the urea carrier.” Journal of Labelled Compounds and Radiopharmaceuticals 42 1 (1994): 289–295.
[2] O’Donoghue, John L. “Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.” Fundamental and Applied Toxicology 6 3 (1986): Pages 551-558.
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