| Identification | Back Directory | [Name]
Nutlin-3b | [CAS]
675576-97-3 | [Synonyms]
CS-986
Nutlin-3b
NUTLIN-3B;NUTLIN 3B
Nutlin-3b USP/EP/BP
(+)-NUTLIN-3;NUTLIN 3B
Nutlin-3b - Nutlin-3, (+)-
4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid
4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3b | [Molecular Formula]
C30H30Cl2N4O4 | [MDL Number]
MFCD11977784 | [MOL File]
675576-97-3.mol | [Molecular Weight]
581.49 |
| Chemical Properties | Back Directory | [density ]
1.36 | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO | [form ]
crystalline solid | [pka]
14.35±0.20(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Description]
(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells. | [Uses]
Nutlin 3b is a small molecule MDM2 antagonist. | [Definition]
ChEBI: Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent. | [References]
[1] tovar c, rosinski j, filipovic z, higgins b, kolinsky k, hilton h, zhao x, vu bt, qing w, packman k, myklebost o, heimbrook dc, vassilev lt. small-molecule mdm2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. proc natl acad sci u s a. 2006 feb 7;103(6):1888-93.
[2] cao c, shinohara et, subhawong tk, geng l, kim kw, albert jm, hallahan de, lu b. radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. mol cancer ther. 2006 feb;5(2):411-7. |
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