| Identification | Back Directory | [Name]
N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide | [CAS]
693288-97-0 | [Synonyms]
CPPHA
N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide
N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
N-[4-Chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
Benzamide, N-[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxy- | [Molecular Formula]
C22H15ClN2O4 | [MDL Number]
MFCD12912405 | [MOL File]
693288-97-0.mol | [Molecular Weight]
406.82 |
| Chemical Properties | Back Directory | [Boiling point ]
539.7±50.0 °C(Predicted) | [density ]
1.505 | [storage temp. ]
-20°C | [solubility ]
DMSO: >20mg/mL | [form ]
solid | [pka]
8.24±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
CPPHA is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG , and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 μM for human and rat mGluR5, respectively). It is selective for mGluR5 over other mGluRs but exhibits submicromolar activity at PDE6, δ- and κ-opioid receptors, and the ether-a-go-go related gene (ERG) potassium channel (Kis = 500, 352, 474, and 813 nM, respectively). CPPHA potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of rat subthalamic nucleus (STN) neurons. | [storage]
Store at -20°C |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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