| Identification | Back Directory | [Name]
14,15-LEUKOTRIENE C4 | [CAS]
75290-60-7 | [Synonyms]
EXC4
EOXIN C4
14,15-LTC4
14,15-LEUKOTRIENE C4
OBQVBASHEWLKCQ-PKBWNXTMSA-N
Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl- | [Molecular Formula]
C30H47N3O9S | [MDL Number]
MFCD00211501 | [MOL File]
75290-60-7.mol | [Molecular Weight]
625.77 |
| Hazard Information | Back Directory | [Description]
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation. | [Uses]
14,15-Leukotriene C4 is an acute inflammatory mediator. | [storage]
Store at -20°C |
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