| Identification | Back Directory | [Name]
EXO1 | [CAS]
75541-83-2 | [Synonyms]
EXO1
EOX 1
NSC 214045
EXOCYTIC INHIBITOR 1
4-FLUORO-BZ-2-ABZ-OME
2-(4-Fluoro-benzoylami
Exo 1 >=98% (HPLC), solid
Exo1 - CAS 75541-83-2 - Calbiochem
2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE
EXOCYTIC INHIBITOR 1;NSC 214045;EXO 1;EXO-1
2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER
Benzoic acid, 2-[(4-fluorobenzoyl)amino]-, methyl ester
Exo1, Exocytic Inhibitor 1, 2-(4-Fluoro-benzoylaMino)-benzoic acid Methyl ester
2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate | [Molecular Formula]
C15H12FNO3 | [MDL Number]
MFCD00028104 | [MOL File]
75541-83-2.mol | [Molecular Weight]
273.26 |
| Hazard Information | Back Directory | [Uses]
Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 μM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus. | [Definition]
ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides. | [Biochem/physiol Actions]
Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies. |
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