| Identification | More | [Name]
Endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane | [CAS]
76272-56-5 | [Synonyms]
1-AMINO-9-METHYL-9-AZABICYCLO[3,3,1]-NONANE
9-METHYL-9-AZA-BICYCLO[3,3,1]NON-3-YL-AMINE
ENDO-3-AMINE-9-METHYL-9-AZABICYCLO[3,3,1]NONAN
ENDO-3-AMINE-9-METHYL-9-AZABICYCLO[3,3,1]NONANE
ENDO-3-AMINE-9-METHYL-AZABICYCLO[3.3.1] NONANE
ENDO-3-AMINO-9-METHYL-9-AZABICYCLO[3.3.1]NONANE
ENDO-9-METHYL-9-AZA-BICYCLO[3.3.1]NON-3-YLAMINE
ENDO-9-METHYL-9-AZABICYCLO3,3,1-NONAN-3-AMINE
ENDO-9-METHYL-9-AZABICYCLO[3,3,1] NONANE-3-AMINE
EMANA
Endo-9-Methyl-9-Azabicyclo-3,3,1-Nonan-3-Amine(ForGranisetronHcl)
b-3-Amino-9-methyl-9-azabicyclo(3.3.1)-nonane, Granisetron Impurity E (free base)
Endo-3-Amine-9-Methyl-Azabicyc
Endo-9-methyl-9-azabicyclo[3,3,1] nonan-3-amine 76272-56-5
ENDO-9-METHYL-9-AZABICYCLO[3,3,1]-NONAN-3-AMINE/EMANA
9-Methyl-9-azabicyclo[3.3.1]nonylamine
endo-9-Methyl-9-azabicyclo[3.3.1]-3-nonylamine
EMANA(Endo-9-methyl-9-azabicyclo[3,3,1]-nonan-3-amine)
Endo-9-Methy-9-Azabicyclo[3,31]Nonan-3-Amine
-3-Amino-9-methyl-9-azabicyclo(3.3.1)-nonane, Granisetron Impurity E (free base) | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C9H18N2 | [MDL Number]
MFCD02093081 | [Molecular Weight]
154.25 | [MOL File]
76272-56-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Oil | [Boiling point ]
115-119°C (18 mmHg) | [density ]
0.968±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
11.09±0.40(Predicted) | [color ]
Colourless to Dark Yellow | [Usage]
Granisetron impurity E. An intermediate of Granisetron | [Stability:]
Hygroscopic | [InChI]
InChI=1/C9H18N2/c1-11-8-3-2-4-9(11)6-7(10)5-8/h7-9H,2-6,10H2,1H3/t7-,8+,9- | [InChIKey]
HTZWHTQVHWHSHN-AYMMMOKONA-N | [SMILES]
CN1[C@H]2CCC[C@@H]1C[C@H](N)C2 |&1:2,6,8,r| | [CAS DataBase Reference]
76272-56-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Oil | [Uses]
Granisetron impurity E. An intermediate of Granisetron | [Uses]
Granisetron impurity E. An intermediate of Granisetron. | [Synthesis]
9-Methyl-9-azabicyclo[3,3,1]nonan-3-one oxime (10 g, 0.06 mol) was used as a raw material and dissolved in methanol (70 mL) and 0.88 ammonia. The hydrogenation reaction was carried out at 50 °C and 50 psi (344.8 kPa) hydrogen pressure for 16 h using 5% rhodium/carbon catalyst (1 g dry weight). Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration. The catalyst bed was washed with methanol and the methanol solution was subsequently evaporated under reduced pressure to afford endo-3-amino-9-methyl-9-azabicyclo[3,3,1]nonane as an oil (8.6 g, 93% yield), which solidified to a waxy solid (8.6 g, 93%) upon standing. EI analysis by GC/MS (JEOL DX303) showed the molecular ion peak m/z 154 (M+). | [References]
[1] Patent: US5856489, 1999, A |
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