ChemicalBook--->CAS DataBase List--->791835-21-7

791835-21-7

791835-21-7 Structure

791835-21-7 Structure
IdentificationBack Directory
[Name]

BI-6C9
[CAS]

791835-21-7
[Synonyms]

N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamide
Butanamide, N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-
[Molecular Formula]

C23H25N3O4S2
[MDL Number]

MFCD07784498
[MOL File]

791835-21-7.mol
[Molecular Weight]

471.59
Chemical PropertiesBack Directory
[density ]

1.36±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Sealed in dry,Store in freezer, under -20°C
[solubility ]

DMSO: 24 mg/mL, soluble
[form ]

solid
[pka]

11.58±0.50(Predicted)
[color ]

off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 μM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 μM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
[storage]

Store at -20°C
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