791835-21-7
791835-21-7 结构式
基本信息
中文别名
化合物BI-6C9N-(4-((4-氨基苯基)硫代)苯基)-4-(4-甲氧基苯基磺酰胺基)丁酰胺
英文别名
N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamideButanamide, N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-
物理化学性质
密度1.36±0.1 g/cm3(Predicted)
储存条件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO: 24 mg/mL, soluble
酸度系数(pKa)11.58±0.50(Predicted)
形态solid
颜色米白色
常见问题列表
生物活性
BI-6C9 是一种高特异性的 BH3 相互作用结构域 (Bid) 抑制剂，可阻止线粒体外膜电位 (MOMP) 和线粒体分裂，并保护细胞免受线粒体凋亡诱导因子 (AIF) 释放和不依赖 caspase 的细胞死亡。体外研究
HT-22 cells shows reduction of cell viability around 4.5 h after Glutamate (3 mM and 5 mM) treatment. BI-6c9 (10 μM; 18 hours) significantly attenuates the loss of cell viability after Glutamate excitotoxicity.
Cell Viability Assay
| Cell Line: | HT-22 cells |
| Concentration: | 10 μM |
| Incubation Time: | 18 hours |
| Result: | Attenuated Glutamate-induced cell death. |