| Identification | More | [Name]
ACRIFLAVINE | [CAS]
8048-52-0 | [Synonyms]
2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
ACRIFLAVINE
ACRIFLAVINE BASE
ACRIFLAVINE NEUTRAL
CI 46000
CI NO 46000
EUFLAVIN
EUFLAVINE
TRYPAFLAVINE
TRYPAFLAVINE FS
XANTHACRIDINE
2,8-diamino-10-methylacridiniumchloridemixturewith2,8-diaminoacridine
3,6-diamino-10-methylacridiniumchloridemixturewith3,6-acridinediamine
3,6-diaminoacridinemixturewith3,6-diamino-10-methylacridiniumchloride
acridinium,3,6-diamino-10-methyl-,chloridemixedwith3,6-acridinediamine
angiflan
assiflavine
bialflavina
bioacridin | [EINECS(EC#)]
999-999-2 | [Molecular Formula]
C27H25ClN6 | [MDL Number]
MFCD00064307 | [Molecular Weight]
468.98 | [MOL File]
8048-52-0.mol |
| Chemical Properties | Back Directory | [Appearance]
deep orange to brownish-red powder | [Melting point ]
179-181 °C
| [Boiling point ]
612.69°C (rough estimate) | [density ]
1.0933 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
H2O: soluble0.33g/mL (lit.)(lit.) | [form ]
Powder | [color ]
Deep orange to brownish-red | [Water Solubility ]
H2O: 0.33g/mL (lit.)(lit.) | [Merck ]
123 | [CAS DataBase Reference]
8048-52-0(CAS DataBase Reference) | [EPA Substance Registry System]
8048-52-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S29:Do not empty into drains . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
3
| [RTECS ]
AR9660000
| [HS Code ]
29339900 | [Safety Profile]
Poison by
subcutaneous route. Questionable
carcinogen with experimental tumorigenic
data. Human mutation data reported. A
topical antiseptic used in the treatment of
gonorrhea. When heated to decomposition
it emits very toxic fumes of NOx and Cl-.
See also 3,6-DIAMINO-10
METHYLACRIDINIUM CHLORIDE. |
| Hazard Information | Back Directory | [Chemical Properties]
Acriflavine hydrochloride is deep orange to brownish-red powder
| [Uses]
Acriflavine is used in applications for dual fluorescence analysis of cellular DNA and protein simultaneously.
| [Uses]
Fluorescent label for high molecular weight RNA | [Biological Activity]
Acriflavine also interacts with HIF-1α (hypoxia-inducible factor 1 α) and HIF-2αand thereby suppresses dimer formation of HIF-1 and transcriptional function. It also has negative effect on tumor growth and vascularization. Acriflavine also exhibits trypanocidalantibacterial and antiviral activities. | [storage]
Store at -20°C | [Purification Methods]
Treat acriflavin twice with freshly precipitated AgOH to remove proflavine, then recrystallise it from absolute methanol [Wen & Hsu J Phys Chem 66 1353 1962]. [Beilstein 22 III/IV 218.] |
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