Identification | Back Directory | [Name]
HUMAN M-CSF | [CAS]
81627-83-0 | [Synonyms]
csf-1 M-CSF MGI-IM mCSF-1 mM-CSF RHM-CSF MGC31930 M-CSF rat Lanimostim HUMAN M-CSF HUMAN CSF-1 HUMAN MGI-IM M-CSF, HUMAN M-CSF from rat M-CSF from mouse NATURAL HUMAN CSF-1 NATURAL HUMAN M-CSF RECOMBINANT HUMAN M-CSF colony-stimulatingfactor1 monocytecolony-stimulatingfactor MACROPHAGE COLONY STIMULATING FACTOR Recombinant Human M-CSF, HUMAN M-CSF Macrophage colony-stimulating factor 1 HUMAN MACROPHAGE COLONY STIMULATING FACTOR Recombinant Rat M-Csf/Csf1 Protein, No Tag MACROPHAGE COLONY STIMULATING FACTOR, HUMAN Recombinant Mouse M-Csf/Csf1 Protein, No Tag cytokines,macrophagecolony-stimulatingfactor Recombinant Human M-CSF/CSF1 Protein, His Tag macrophagehumanrecombinantexpressedinyeast95+% macrophage colony-stimulating factor from mouse ANTI-M-CSF (CENTER) antibody produced in rabbit Monoclonal Anti-CSF1 antibody produced in mouse Processed macrophage colony-stimulating factor 1 MACROPHAGE COLONY STIMULATOR FACTOR (M-CSF) HUMAN NATURAL HUMAN MACROPHAGE-COLONY STIMULATING FACTOR Macrophage Colony-StimulatingFactor, Human, Recomb. FOR USE IN THE MANUFACTURE OF MEDICAMENTS OF HS NO. 3002 MACROPHAGE COLONY-STIMULATING FACTOR, HUMAN, RECOMBINANT Macrophage Colony-Stimulating Factor, Human, Recombinant, E. coli MACROPHAGE-COLONY STIMULATING FACTOR, HU MAN RECOMBINANT EXPRESSED IN E. COLI | [MDL Number]
MFCD00241918 |
Hazard Information | Back Directory | [Uses]
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
| [Uses]
Antineoplastic; anti-infective
growth factor that acts on both progenitor and mature
cells of the macrophage line. | [General Description]
M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits. | [Biochem/physiol Actions]
M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer. |
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Sigma-Aldrich
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