ChemicalBook--->CAS DataBase List--->83654-05-1

83654-05-1

83654-05-1 Structure

83654-05-1 Structure
IdentificationBack Directory
[Name]

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
[CAS]

83654-05-1
[Synonyms]

U-57908
Rg 80267
RHC-80267
RXSVYGIGWRDVQC-UHFFFAOYSA-N
RHC-80267 - CAS 83654-05-1 - Calbiochem
1,6-bis(cyclohexyloximinocarbonyl)hexane
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908
O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone
Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime
N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine)
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE ISO 9001:2015 REACH
Cyclohexanone, 1,1'-[O,O'-[1,6-hexanediylbis(iminocarbonyl)]dioxime]
(cyclohexylideneamino) N-[6-[(cyclohexylideneamino)oxycarbonylamino]hexyl]carbamate
Cyclohexanone O-((6-((((cyclohexylideneamino)oxy)carbonyl)amino)hexyl)carbamoyl) oxime
[Molecular Formula]

C20H34N4O4
[MDL Number]

MFCD00210844
[MOL File]

83654-05-1.mol
[Molecular Weight]

394.52
Chemical PropertiesBack Directory
[Melting point ]

118-121℃
[density ]

1.21±0.1 g/cm3(Predicted)
[RTECS ]

GW1485000
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO: 9 mg/mL
[form ]

solid
[pka]

13.81±0.46(Predicted)
[color ]

white
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1
[Uses]

RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.
[Definition]

ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.
[General Description]

Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.
[Biological Activity]

Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).
[Biochem/physiol Actions]

Product does not compete with ATP.
[storage]

Store at +4°C
[References]

1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006 2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247 3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509 4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673 5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717
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