83654-05-1

中文名称 1,6-双(环己基脒基羰基氨基)己烷

英文名称 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

CAS 83654-05-1

分子式 C20H34N4O4

分子量 394.52

MOL 文件 83654-05-1.mol

更新日期 2024/07/21 13:45:55

83654-05-1 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

1,6-双(环己基脒基羰基氨基)己烷

英文别名

U-57908
Rg 80267
RHC-80267
RXSVYGIGWRDVQC-UHFFFAOYSA-N
RHC-80267 - CAS 83654-05-1 - Calbiochem
1,6-bis(cyclohexyloximinocarbonyl)hexane
1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE
1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908
O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioximecyclohexanone

所属类别

有机原料：无环单胺、多胺及其衍生物和盐

物理化学性质

熔点118-121℃

密度1.21±0.1 g/cm3(Predicted)

RTECS号GW1485000

储存条件Sealed in dry,Room Temperature

溶解度DMSO: 9 mg/mL

溶解度二甲基亚砜：9 mg/毫升

酸度系数(pKa)13.81±0.46(Predicted)

形态solid

颜色white

稳定性从购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P305+P351+P338

安全说明22-24/25

WGK Germany3

常见问题列表

简介

1,6-双(环己基脒基羰基氨基)己烷可抑制多种细胞类型和组织中的DAG 脂肪酶活性，包括犬血小板、牛肾上腺嗜铬细胞、人肾上腺肾小球细胞、大鼠甲状腺叶和胰腺小叶。犬血小板中的 IC50 为 4 μM。

生物活性

RHC 80267 (U-57908) 是一种有效的、具有选择性的 diacylglycerol lipase (DAGL, DAG lipase) 的抑制剂，其对 cholinesterase 活性的IC50值为4 μM。RHC 80267 可抑制 cyclooxygenase (COX) 的活性，phospholipase C (PLC) 的活性和 phosphatidylcholine (PC) 的水解作用。

靶点

Target	Value
cholinesterase (Cell-free assay)	4 μM

体外研究

The potentiation by RHC 80267 of the relaxation to acetylcholine could be caused by the inhibition of cholinesterase: (1) RHC 80267 does not affect the responses to carbachol, the carbamyl derivative of acetylcholine which only differs from acetylcholine by its resistance to hydrolysis by cholinesterase, and (2) the effect of RHC 80267 is mimicked by the inhibitor of cholinesterase neostigmine, RHC 80267 showing no additional effect in the presence of a maximally effective concentration of neostigmine. The determination of the effect of RHC 80267 on the cholinesterase activity of brain homogenate confirmed that RHC 80267 inhibits this enzyme in the same range of concentrations increasing the relaxation to acetylcholine, namely at 1-10 μM.

体内研究

RHC 80267 (40 μM) enhances contractions induced by U46619 (a thromboxane A2 analog) in human and rat pulmonary arteries (hPAs and rPAs, respectively) and by angiotensin II (ANG II) in rPAs in an endothelium-dependent manner.