| Identification | More | [Name]
Pinacidil | [CAS]
85371-64-8 | [Synonyms]
(+/-)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine
Pinacidil
(±)-N-Cyano-N’-4-pyridinyl-N’’-(1，2，2-trimethylpropyl)guanidine monohydrate
Hndac
Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate | [EINECS(EC#)]
622-053-4 | [Molecular Formula]
C13H19N5 | [MDL Number]
MFCD00242745 | [Molecular Weight]
245.32 | [MOL File]
85371-64-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
164-165° | [storage temp. ]
RT | [solubility ]
ethanol: 14 mg/mL
| [form ]
solid
| [pka]
pKa 空 (Uncertain) | [color ]
white
| [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. | [CAS DataBase Reference]
85371-64-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Toxicity]
LD50 in mice, rats (mg/kg): 600, 570 orally (Petersen, 1978) |
| Hazard Information | Back Directory | [Description]
Pinacidil is a peripheral vasodilator useful in the management of arterial hypertension of
all degrees of seventy, usually in combination with a diuretic or beta-blocker. Preclinical
evidence suggests that its hypotensive effect may be attributed to potassium channel
activation. | [Originator]
Leo (Denmark) | [Uses]
Pinacidil monohydrate has been used:
- in repolarization studies by infusing into left anterior descending artery (LAD)
- to induce ATP-sensitive K+ (KATP) current in ventricular myocytes for electrophysiological studies
- as a KATP opener to treat myocardial cells
| [Uses]
cardiac stimulant | [Uses]
Pinacidil Monohydrate is a K+ channel opener, used to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. Vasodilator. Antihypertensive agent. | [Definition]
ChEBI: Pinacidil is an organic molecular entity. | [Brand name]
Pindac (Leo). | [Biochem/physiol Actions]
Pinacidil is a KATP channel agonist. It protects cardiomyocytes by preventing loss of mitochondrial membrane potential. It prevents the caspase 3 activation in hypoxia/reoxygenation injury. | [References]
1) Hermsmeyer et al. (1988), Pinacidil actions on ion channels in vascular muscle; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S17
2) Gollasch et al. (1995), Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells; J. Pharmacol. Exp. Therap., 275 681
3) Cohen & Kurz (1988), Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S5
4) Teshima et al. (2003), Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress; Stroke, 34 1796
5) Xie et al. (2010), K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection; J. Neurosci. Res., 88 428
6) Zhang et al. (2008), Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats; Neurosci. Bull., 24 7 |
|
| Company Name: |
INTATRADE GmbH
|
| Tel: |
+49 3493/605464 |
| Website: |
www.intatrade.de |
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
China Langchem Inc.
|
| Tel: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0.htm |
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