| Identification | Back Directory | [Name]
Dopexamine hydrochloride | [CAS]
86484-91-5 | [Synonyms]
Dopexamine HCl
DOPEXAMINE 2HCL
dopexamine hydrochloride
Dopexamine dihydrochloride CRS
4-(2-((6-(phenethylamino)hexyl)amino)ethyl)benzene-1,2-diol dihydrochloride
4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol dihydrochloride
1,2-Benzenediol, 4-(2-((6-((2-phenylethyl)amino)hexyl)amino)ethyl)-, dihydrochloride
Beta Receptor,Adrenergic Receptor,Dopexamine,Inhibitor,Dopexamine hydrochloride,inhibit
1,2-Benzenediol,4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-, hydrochloride (1:2) | [Molecular Formula]
C22H34Cl2N2O2 | [MDL Number]
MFCD00887597 | [MOL File]
86484-91-5.mol | [Molecular Weight]
429.424 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
213-215°C | [storage temp. ]
2-8°C | [solubility ]
Soluble in water, sparingly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone. | [form ]
Solid | [color ]
White to Light Grey | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine has been used to improve myocardial and renal performance in patients suffering from low cardiac output states. | [Brand name]
Dopacard (Fisons). | [Clinical Use]
Inotropic support in exacerbations of heart failure and
heart failure associated with cardiac surgery | [Drug interactions]
Potentially hazardous interactions with other drugs
Anaesthetics: risk of ventricular arrhythmias with
isoflurane - avoid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Beta-blockers: risk of severe hypertension
Dopaminergics: avoid with rasagiline.
Sympathomimetics: effects of adrennoradrenaline possibly enhanced. | [Metabolism]
Dopexamine is rapidly eliminated from blood with a halflife of approximately 6-7 minutes in healthy volunteers
and around 11 minutes in patients with cardiac failure.
Subsequent elimination of the metabolites is by urinary
and biliary excretion. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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