86484-91-5
中文名称
盐酸多培沙明
英文名称
Dopexamine hydrochloride
CAS
86484-91-5
分子式
C22H34Cl2N2O2
分子量
429.424
MOL 文件
86484-91-5.mol
86484-91-5 结构式
基本信息
中文别名
盐酸多培沙明二氯化多巴检查
盐酸多培沙明 EP标准品
4-[2-[[6-[(2-苯乙基)氨基]己基]氨基]乙基]-1,2-苯二酚二盐酸盐
英文别名
Dopexamine HClDOPEXAMINE 2HCL
dopexamine hydrochloride
Dopexamine dihydrochloride CRS
4-(2-((6-(phenethylamino)hexyl)amino)ethyl)benzene-1,2-diol dihydrochloride
4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-1,2-benzenediol dihydrochloride
1,2-Benzenediol, 4-(2-((6-((2-phenylethyl)amino)hexyl)amino)ethyl)-, dihydrochloride
1,2-Benzenediol,4-[2-[[6-[(2-phenylethyl)amino]hexyl]amino]ethyl]-, hydrochloride (1:2)
Beta Receptor,Adrenergic Receptor,Dopexamine,Inhibitor,Dopexamine hydrochloride,inhibit
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点213-215°C
储存条件2-8°C
溶解度Soluble in water, sparingly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
形态Solid
颜色White to Light Grey
稳定性Hygroscopic
常见问题列表
生物活性
Dopexamine hydrochloride 是一种 β2 肾上腺素能受体激动剂。靶点
β2 adrenergic receptor
体外研究
Dopexamine is a dopamine analogue with agonist activity at β2 and dopaminergic receptors. Dopexamine can attenuate the systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow. Dopexamine is a dopamine analog that stimulates β-adrenergic and dopamine 1 and 2 receptors, conferring some vasodilatory effects. Dopexamine reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics, either blood pressure or stroke volume.