| Identification | Back Directory | [Name]
WAY-255348 | [CAS]
872141-23-6 | [Synonyms]
WAY-255348
5-(7-fluoro-3,3-dimethyl-2-oxo-1H-indol-5-yl)-1-methylpyrrole-2-carbonitrile | [Molecular Formula]
C16H14FN3O | [MDL Number]
MFCD18782604 | [MOL File]
872141-23-6.mol | [Molecular Weight]
283.3 |
| Hazard Information | Back Directory | [Description]
WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways. |
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