872141-23-6
英文名称
WAY-255348
CAS
872141-23-6
分子式
C16H14FN3O
分子量
283.3
MOL 文件
872141-23-6.mol
更新日期
2024/09/02 13:38:58
872141-23-6 结构式
应用领域
用途一
WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-induced nuclear accumulation, phosphorylation and promoter interactions of the PR. WAY-255348 bound PR conformation was similar to that of a progesterone agonist-bound PR and distinct from steroidal antagonist-bound PR conformations. WAY-255348 inhibits PR action through a novel molecular mechanism that is distinct from previously studied PR modulators and may be a useful tool to further understanding of PR signaling pathways.