| Identification | Back Directory | [Name]
POLY(ETHYLENE GLYCOL) (N) DISTEARATE | [CAS]
9005-08-7 | [Synonyms]
DGD
s1009
s1013
EG 11
S 200
Vinlub
AM 112
AM 113
Geleol
GMS-SE
Dub GMS
nonex80
Polynol
Stearine
stabogel
Monogrol
Excel 150
Margamuls
Atmer 122
Atmer 123
Cutina MD
Poem S 95
Poem S 200
Sunsoft 30
Rylo MD 50
Estol 1461
Estol 1462
lipal15-ds
emerest2642
Emulgator C
Imwitor 800
Lexemul 515
Lexemul 530
Atmul P 40S
PEG(150)DS.
Dracorin GMS
Emalex GMS-F
Tegomuls 90S
Rikemal S 95
Pationic 1052
Rikemal S 200
Tegin special
Tegomuls 4100
Cadenax GS 90
Lasemul 92N40
Monomuls 90S18
POE distearate
Rikemal S 200P
Pationic 1052K
Stepan GMS S.E
T 4 (glyceride)
Safacid 16/18AM
Safacid 16/18MS
Nikkol MGS-F 40
PEG-3distearate
PEG-6 DISTEARATE
PEG-8 DISTEARATE
PEG-50DISTEARATE
Precirol WL 2155
PEG-12 DISTEARATE
PEG-20 DISTEARATE
PEG-32 DISTEARATE
PEG-75 DISTEARATE
PEG-120 DISTEARATE
PEG-150 DISTEARATE
PEG-175 DISTEARATE
PEG-250 DISTEARATE
PEG 600 DISTEARATE
PEG 400 DISTEARATE
PEG 200 DISTEARATE
PEG 300 DISTEARATE
PEG 1540 DISTEARATE
PEG 1000 DISTEARATE
PEG 6000 DISTEARATE
PEG 4000 DISTEARATE
Pegosperse(R) 300 D
Pegosperse(R) 300 DS
Pegosperse(R) 400 DS
polyglycoldistearate
carbowax1000distearate
Precirol Special WL 2155
PEG400distearate,m.p.35-37c
Glycerin stearic acid ester
Glycerol stearic acid ester
Poly(oxyethylene) distearate
DIETHYLENE GLYCOL DISTEARATE
Polyethyleneglycol3distearate
Polyoxyethylene bis(stearate)
Polyoxyethylene distearyl ether
polyethyleneglycol300distearate
POLY(ETHYLENE GLYCOL) DISTEARATE
POLYETHYLENEGLYCOL1000DISTEARATE
Octadecanoic acid glycerol ester
polyethyleneglycoldistearate#1000
POLYETHYLENE GLYCOL 400 DISTEARATE
POLYETHYLENE GLYCOL 6000 DISTEARATE
POLY(ETHYLENE GLYCOL) (N) DISTEARATE
polycethylene glycol-400 distearate.
Oxydi-2,1-ethanediyl dioctadecanoate
Polyethylene glycol dioctadecyl ether
polyoxyethylene glycol (400) bisstearate
Poly(ethylene glycol) distearate average Mn ~930
.alpha.-Stearoyl-.omega.-(stearoyloxy)poly(oxyethylene)
Poly(ethylene glycol) distearate,Polyoxyethylene bis(stearate)
Poly(oxy-1,2-ethanediyl),a-(1-oxooctadecyl)-w-[(1-oxooctadecyl)oxy]-
alpha-(1-oxooctadecyl)-omega-[(1-oxooctadecyl)oxy]-poly(oxy-2-ethanediyl)
Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-(1-oxooctadecyl)oxy-
Poly(oxy-1,2-ethanediyl),alpha-(1-oxooctadecyl)-omega-[(1-oxooctadecyl)oxy] ( EO 204 mol or average MW 10000 - 12000 g/mol) | [Molecular Formula]
C40H78O5 | [MDL Number]
MFCD00084419 | [MOL File]
9005-08-7.mol | [Molecular Weight]
639.04 |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Uses]
Pegosperse(R) 300 DS is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry. | [Uses]
Pegosperse(R) 400 DS is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry. | [Production Methods]
Polyethylene glycol distearate is prepared by the direct reaction of
fatty acids, particularly stearic acid, with ethylene oxide. | [Pharmaceutical Applications]
Polyethylene glycol distearate is generally used as emulsifiers in oil-inwater-
type creams and lotions. Its hydrophilicity or lipophilicity
depends on the number of ethylene oxide units present: the larger
the number, the greater the hydrophilic properties. Polyoxyl 40
stearate has been used as an emulsifying agent in intravenous
infusions.
Polyoxyethylene stearates are particularly useful as emulsifying
agents when astringent salts or other strong electrolytes are present.
It can also be blended with other surfactants to obtain any
hydrophilic–lipophilic balance for lotions or ointment formulations. | [Safety]
Although Polyethylene glycol distearate is primarily used as emulsifying
agents in topical pharmaceutical formulations, certain materials,
particularly polyoxyl 40 stearate, have also been used in
intravenous injections and oral preparations.
Polyethylene glycol distearate has been tested extensively for
toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as
essentially nontoxic and nonirritant materials.
Polyoxyl 8 stearate
(hamster, oral): 27 g/kg
(rat, oral): 64 g/kg
Polyoxyl 20 stearate
(mouse, IP): 0.2 g/kg
(mouse, IV): 0.87 g/kg | [storage]
Polyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification.
The bulk material should be stored in a well-closed container, in a dry place, at room temperature. | [Incompatibilities]
Polyethylene glycol distearate is unstable in hot alkaline solutions
owing to hydrolysis, and will also saponify with strong acids or
bases. Discoloration or precipitation can occur with salicylates,
phenolic substances, iodine salts, and salts of bismuth, silver, and
tannins.Complex formation with preservatives may also
occur.The antimicrobial activity of some materials such as
bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium
penicillin, and tetracycline may be reduced in the presence of
polyoxyethylene stearate concentrations greater than 5% w/w. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (dental
solutions; IV injections; ophthalmic preparations; oral capsules
and tablets; otic suspensions; topical creams, emulsions, lotions,
ointments, and solutions; and vaginal preparations). Included in
nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients. |
| Safety Data | Back Directory | [WGK Germany ]
1
| [RTECS ]
TQ4375000
| [Safety Profile]
Poison by intravenous
route. When heated to decomposition it
emits acrid smoke and irritating fumes. See
also POLYETHYLENE GLYCOL. |
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