| Identification | Back Directory | [Name]
EC 4.2.1.2 | [CAS]
9032-88-6 | [Synonyms]
MCL
LRCC
MCUL1
FUMARASE
EC 4.2.1.2
Fumarase human
Einecs 232-887-7
FUMARATE HYDRATASE
L-MALATE HYDROLYASE
Hydratase, fumarate
Native Porcine Fumarase
fumarase from rabbit liver
fumarase from porcine heart
FUMARASE PRESTAINED FROM PORCINE HEART
L-Malate hydrolyase, Fumarate hydratase | [EINECS(EC#)]
232-887-7 | [MDL Number]
MFCD00131111 |
| Chemical Properties | Back Directory | [Definition]
An enzyme that catalyzes the interconversion of
fumaric acid and malic acid. It is an important reactant in the tricarboxylic acid cycle. | [storage temp. ]
2-8°C
| [form ]
ammonium sulfate suspension
| [Specific Activity]
≥300units/mg protein (biuret) | [EPA Substance Registry System]
Hydratase, fumarate (9032-88-6) |
| Hazard Information | Back Directory | [Uses]
Fumarase from porcine heart has been used:
- as a positive control in isocitrate dehydrogenase and α-ketoglutarate dehydrogenase assay
- for immobilized enzyme based stability assay
- in fumarate hydratase assays in human lung carcinoma cells (A549)
| [General Description]
Fumarase (FH in human) is a well-known tricarboxylic-acid-cycle enzyme found in both the cytoplasm and mitochondria of all eukaryotes. | [Biochem/physiol Actions]
Fumarase catalyzes the reversible hydration of fumarate to malate. In its mitochondrial form, fumarate is involved in the Krebs Cycle, while the cytosolic form is involved in amino acid metabolism. |
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