| Identification | Back Directory | [Name]
CYTOCHROME B5, HUMAN | [CAS]
9078-32-4 | [Synonyms]
cyb5a
CYTOCHROME B5
Cytochrome b2
CYTOCHROME B5, HUMAN
Dehydrogenase, lactate (cytochrome)
Cytochrome b5, Human, Recomb.,E. coli
Anti-CYB5 antibody produced in rabbit
Recombinant Human CYB5A Protein, His Tag
L-Lactate: ferricytochrome c oxidoreductase
L-lactic dehydrogenase type iv-ss from*bakers yea
L-LACTIC DEHYDROGENASE TYPE IV-SS FROM*B AKERS YEAST
L-Lactic Dehydrogenase (cytochrome) from baker's yeast (S.cerevisiae)
(S)-Lactate: NAD+ oxidoreductase, L-Lactate: ferricytochromec oxidoreductase, L-LDH, Cytochrome b2, LAD, LD | [EINECS(EC#)]
232-986-5 | [MDL Number]
MFCD00131467 |
| Safety Data | Back Directory | [WGK Germany ]
3 | [Toxicity]
A microsomal cytochrome involved in such
metabolic activities as fatty acid desaturation. It may be
involved in the reduction of cytochrome P450. The possibility
that the second electron in cytochrome P450 reduction in vivo
is derived from NADH via cytochrome b5 is still to be
resolved. This pathway is not, however, essential for all cytochrome
P450-dependent monooxygenations since many occur
in in vitro systems reconstituted from purified NADPHcytochrome P450 reductase, cytochrome P450 and phosphatidylcholine
in the presence of NADPH and oxygen.
Nevertheless, cytochrome b5 is stimulatory for some monooxygenations
and may facilitate oxidative activity in the intact
endoplasmic reticulum. |
| Hazard Information | Back Directory | [General Description]
Cytochrome b5 (CYB5A) gene codes for cytochrome b5 protein. It is located on human chromosome 18. It is co-expressed in the Leydig cells of the testis and theca cells of the ovary. | [Biochem/physiol Actions]
Cytochrome b5 (CYB5A) mediates NADH-dependent reduction of methemoglobin (erythrocytes), electron transfer to fatty-acid desaturases (mainly liver) and steroid and xenobiotics metabolism by cytochrome P450 enzymes. It is essential for androstenedione synthesis. CYB5A helps in the efficient synthesis of gonadal androgen. |
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