| Identification | Back Directory | [Name]
HSP70 modulator 115-7c | [CAS]
908074-72-6 | [Synonyms]
Compound 115-7c
HSP70 modulator 115-7c
1(2H)-Pyrimidinebutanoic acid, 4-(2,4-dichlorophenyl)-3,4-dihydro-6-methyl-2-oxo-5-[(phenylmethoxy)carbonyl]- | [Molecular Formula]
C23H22Cl2N2O5 | [MOL File]
908074-72-6.mol | [Molecular Weight]
477.34 |
| Chemical Properties | Back Directory | [Boiling point ]
688.6±55.0 °C(Predicted) | [density ]
1.360±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 20 mg/ml). | [form ]
solid | [pka]
4.73±0.10(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1?The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau levels in cell lines overexpressing tau.2?Induces solubilization of polyglutamine and exacerbates polyQ-mediated toxicity.3,4?Compound 115-7c is an important probe for understanding HSP70 functions.4 | [Definition]
ChEBI: 4-[6-(2,4-dichlorophenyl)-4-methyl-2-oxo-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl]butanoic acid is a carboxylic ester. It is functionally related to a benzyl alcohol. | [References]
1) Wisen?et al. (2010),?Binding of a small molecule at the protein-protein interface regulates the chaperone activity of hsp70-hsp40;? ACS Chem. Biol.,?5?611
2) Jinwal?et al. (2010),?Hsp70 ATPase Modulators as Therapeutics for Alzheimer’s and other Neurodegenerative Diseases;? Mol. Cell Pharmacol.,?2?43
3) Chafekar?et al. (2012),?Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation;? ACS Chem. Biol.,?7?1556
4) Walter?et al. (2011),?Ordered assembly of heat shock proteins Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes;? J. Biol. Chem.,?286?40486 |
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