| Identification | Back Directory | [Name]
4-Pyridinecarboxylicacid, 2-phenylhydrazide | [CAS]
91396-88-2 | [Synonyms]
PluriSln
uriSIn 1
NSC 14613
PluriSIn#1
plurisln 1
PluriSIn PluriSIn
PluriSIn #1, >=98%
PluriSln 1 USP/EP/BP
PluriSln 1, NSC 14613
NSC 14613, PluriSln 1
PluriSIn #1 (NSC 14613)
NSC14613,PluriSln1, >98%
1,4-Pyridinecarboxylicacid
NSC 14613;NSC-14613;NSC14613
N'-PHENYLISONICOTINOHYDRAZIDE
N'-phenylpyridine-4-carbohydrazide
Isonicotinic acid 2-phenylhydrazide
4-Pyridinecarboxylicacid, 2-phenylhydrazide
2-Phenylhydrazide-4-pyridinecarboxylic acid
PluriSIn #1 - NSC 14613 | Pluripotent cell-specific inhibitor #1
4-Pyridinecarboxylic acid 2-phenylhydrazide PluriSln 1 NSC 14613
NSC 14613 4-Pyridinecarboxylic acid 2-phenylhydrazide | [EINECS(EC#)]
804-702-5 | [Molecular Formula]
C12H11N3O | [MDL Number]
MFCD02344904 | [MOL File]
91396-88-2.mol | [Molecular Weight]
213.235 |
| Chemical Properties | Back Directory | [Melting point ]
177-178℃ | [Boiling point ]
335.7±15.0 °C(Predicted) | [density ]
1.251±0.06 g/cm3(Predicted) | [storage temp. ]
?20°C | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
powder | [pka]
10.69±0.23(Predicted) | [color ]
white to beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1?The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln-1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2?and chondrogenic cells3. | [Uses]
NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs. | [Enzyme inhibitor]
This stearoyl-CoA sesaturase 1 inhibitor, or SCD1 (FW = 213.24 g/mol;
CAS 91396-88-2; Solubility: 43 mg/mL DMSO; <1 mg/mL H2O), also
known as NSC 14613 an 4-pyridinecarboxylic acid, 2-phenylhydrazide,
selectively eliminates human Pluripotent Stem Cells (hPSCs), while sparing
a large array of progenitor and differentiated cells, thus providing a
promising approach for minimizing the tumorigenic risk from residual
undifferentiated cells. Closer examination identified PluriSIn #1 as an
SCD1, thereby indicating a role for lipid metabolism in hPSC survival.
PluriSIn #1 is likewise cytotoxic to mouse blastocysts, again suggesting a
dependence on oleate in cells in a pluripotent state. SCD is key and highly
regulated enzyme which catalyzes the D9-cis desaturation of a range of
palmitoyl- and stearoyl-CoA to palmitoleoyl- and oleoyl-CoA respectively.
| [storage]
+4°C | [References]
1) Ben-David?et al. (2013),?Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen; Cell Stem Cell.?12?167
2) Zhang?et al. (2014),?Inhibition of stearoyl-coA desaturase eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium; Cell Cycle?13?762
3) Cheng?et al. (2014),?Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors; Stem Cells Transl. Med.?3?1287 |
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