| Identification | More | [Name]
7-Hydroxycoumarin | [CAS]
93-35-6 | [Synonyms]
2H-1-BENZOPYRAN-2-ONE, 7-HYDROXY-
3-BUTYLIDEN-4,5-DIHYDRO-3H-ISOBENZOFURAN-1-ONE
3-butylidene-4,5-dihydro-1(3h)-isobenzofuranone
3-BUTYLIDENE-4,5-DIHYDROPHTHALIDE
7-Hydroxy-2H-1-benzopyran-2-one
7-HYDROXYCOUMARIN
AKOS 213-68
HYDRANGIN
LIGUSTILIDE
LIGUSTILIDE, Z-
SKIMMETIN
UMBELLIFERON
UMBELLIFERONE
Z-LIGUSTILIDE
7 HC
7-hydroxy-2h-1-benzopyran-2-on
7-Hydroxy-2H-chromen-2-one
7-hydroxy-coumari
7-Oxycoumarin
beta-Umbelliferone | [EINECS(EC#)]
202-240-3 | [Molecular Formula]
C9H6O3 | [MDL Number]
MFCD01861511 | [Molecular Weight]
162.14 | [MOL File]
93-35-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Light Brownish Powder | [Melting point ]
230 °C (dec.)(lit.)
| [Boiling point ]
248.82°C (rough estimate) | [density ]
1.2599 (rough estimate) | [refractive index ]
1.5380 (estimate) | [storage temp. ]
2-8°C | [solubility ]
dioxane: soluble | [form ]
Powder and Agglomerate | [pka]
7.11(at 25℃) | [color ]
Off-white to beige-brownish | [Odor]
develops odor of coumarin on heating | [PH Range]
Non/ uorescence (6.5) to blue / uorescence (8.0) | [Water Solubility ]
1 g/100 mL (100 ºC) | [Usage]
A metabolite of Coumarin. The aglucon of skimmin. Present in many plants | [λmax]
320nm | [Detection Methods]
HPLC,NMR | [Merck ]
14,9847 | [BRN ]
127683 | [Major Application]
Fluorescent brighteners, fungicides, cosmetics, antitrypanosomal, antileishmanial activities, antifungal, antibacterial, antiinflammatory, antiHIV, detection of microorganisms, treatment of impaired neurotransmission disorders, Alzheimer’s disease, vascular and lymphatic edema cancer, early diagnosis of stroke, dental material, drug-coated coronary stent system | [InChIKey]
ORHBXUUXSCNDEV-UHFFFAOYSA-N | [LogP]
1.580 (est) | [CAS DataBase Reference]
93-35-6(CAS DataBase Reference) | [NIST Chemistry Reference]
7-Hydroxycoumarin(93-35-6) | [EPA Substance Registry System]
93-35-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
GN6820000
| [HS Code ]
29322980 | [Toxicity]
LD50 intravenous in mouse: 450mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
Light Brownish Powder | [Uses]
A metabolite of Coumarin. The aglucon of skimmin. Present in many plants | [Uses]
antifungal, phytoalexin | [Uses]
In sunscreen lotions and creams; as intracellular and pH sensitive fluorescent indicator and blood-brain barrier probe. | [Definition]
ChEBI: A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. | [General Description]
Umbelliferone is a naturally occurring coumarin, present in a variety of medicinal plants from the Apiaceae (Umbelliferae) family and also in plants from other families such as mouse-ear hawkweed. | [storage]
Store at -20°C | [Purification Methods]
It crystallises from water (m 232-232.2o) or EtOH (m 232o). It sublimes at 160o/0.001mm. Fluorescence: Em max 452nm/Exc 325nm in 50% EtOH. [Beilstein 18 H 27, 18 I 306, 18 II 16, 18 III/IV 294, 18/1 V 386.] |
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