946387-07-1

Directory

946387-07-1 Structure

Identification	Back Directory
[Name] 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
[CAS] 946387-07-1
[Synonyms] RN 1734 TRPV4 Antagonist I, RN-1734 TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734) 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
[Molecular Formula] C14H22Cl2N2O2S
[MDL Number] MFCD00129453
[MOL File] 946387-07-1.mol
[Molecular Weight] 353.31

Safety Data	Back Directory
[WGK Germany ] nwg

Hazard Information	Back Directory
[Uses] RN 1734 is a novel TRPV4 modulator.
[Uses] RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.
[General Description] A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca²⁺ influx (IC₅₀ = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC₅₀ >30 μM).
[Biological Activity] Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).
[Biochem/physiol Actions] RN-1734 is a selective TRPV4 antagonist.
[storage] Store at -20°C

Spectrum Detail	Back Directory
[Spectrum Detail] 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide(946387-07-1)¹HNMR

946387-07-1 suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Website:	www.atkchemical.com

Company Name:	Shanghai Acmec Biochemical Technology Co., Ltd.
Tel:	+86-18621343501; +undefined18621343501 , +undefined18621343501
Website:	http://www.acmec.com.cn/

Company Name:	SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel:	+8613817748580 , +8613817748580
Website:	www.kean-chem.com

Company Name:	Amadis Chemical Company Limited
Tel:	571-89925085
Website:	http://www.amadischem.com

Company Name:
Tel:	821-50328103-801 18930552037
Website:	https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Company Name:	Shanghai YuanYe Biotechnology Co., Ltd.
Tel:	021-61312847; 18021002903
Website:	http://www.shyuanye.com

Company Name:	Tianjin Kailiqi Biotechnology Co., Ltd.
Tel:	15076683720
Website:	http://www.cw-bio.com

Company Name:	MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel:	13761635123
Website:	http://www.linyuepharm.com/

Tags:946387-07-1 Related Product Information

22120-39-4 98-82-8 2210-25-5 102-97-6 872-50-4 1781835-13-9 1342278-01-6 1242156-23-5

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login