ChemicalBook--->CAS DataBase List--->95568-41-5

95568-41-5

95568-41-5 Structure

95568-41-5 Structure
IdentificationBack Directory
[Name]

ALPHA2-MACROGLOBULIN
[CAS]

95568-41-5
[Synonyms]

A2M
ALPHA2M
ALPHA2MG
A-2-M, HUMAN
ALPHA2 M, HUMAN
HUMAN ALPHA-2-M
ALPHA2 MG, HUMAN
ALPHA2-MACROGLOBULIN
ALPHA2-MACROGLOBIN, HUMAN
Human A2M Protein, His Tag
ALPHA2-MACROGLOBULIN, HUMAN
HUMAN ALPHA-2-MACROGLOBULIN
ALPHA-2 MACROGLOBULIN PLASMA
MACROGLOBULIN, ALPHA-2-, HUMAN
Macroglobulin from human plasma
ALPHA2-MACROGLOBULIN, HUMAN PLASMA
Human Alpha-2 Microglobulin Protein
Human Alpha-2 Macroglobulin Protein
α2-Macroglobulin from human plasma
Macroglobulin froM huMan plasMa lyophil.
Alpha-2-macroglobulin, Alpha-2-M, A2M, CPAMD5, FWP007, S863-7, alpha 2M, DKFZp779B086.
[MDL Number]

MFCD00130472
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

H2O: 5 mg/mL, clear to faintly turbid, colorless to faintly yellow
[form ]

lyophilized powder
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P271-P280
[Hazard Codes ]

B
[Safety Statements ]

22-24/25
[WGK Germany ]

3
[F ]

10-21
Hazard InformationBack Directory
[Uses]

α2-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation.
[Biochem/physiol Actions]

α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
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