| Identification | Back Directory | [Name]
ALPHA2-MACROGLOBULIN | [CAS]
95568-41-5 | [Synonyms]
A2M
ALPHA2M
ALPHA2MG
A-2-M, HUMAN
ALPHA2 M, HUMAN
HUMAN ALPHA-2-M
ALPHA2 MG, HUMAN
ALPHA2-MACROGLOBULIN
ALPHA2-MACROGLOBIN, HUMAN
Human A2M Protein, His Tag
ALPHA2-MACROGLOBULIN, HUMAN
HUMAN ALPHA-2-MACROGLOBULIN
ALPHA-2 MACROGLOBULIN PLASMA
MACROGLOBULIN, ALPHA-2-, HUMAN
Macroglobulin from human plasma
ALPHA2-MACROGLOBULIN, HUMAN PLASMA
Human Alpha-2 Microglobulin Protein
Human Alpha-2 Macroglobulin Protein
α2-Macroglobulin from human plasma
Macroglobulin froM huMan plasMa lyophil.
Alpha-2-macroglobulin, Alpha-2-M, A2M, CPAMD5, FWP007, S863-7, alpha 2M, DKFZp779B086. | [MDL Number]
MFCD00130472 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
H2O: 5 mg/mL, clear to faintly turbid, colorless to faintly yellow | [form ]
lyophilized powder | [biological source]
human plasma | [Water Solubility ]
water: soluble 10mg protein/mL, clear, colorless |
| Hazard Information | Back Directory | [Uses]
α2-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation. | [Biochem/physiol Actions]
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation. |
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