103141-09-9

中文名称 N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺

英文名称 FPL 62064

CAS 103141-09-9

分子式 C16H15N3O

分子量 265.31

MOL 文件 103141-09-9.mol

更新日期 2024/07/21 13:45:55

103141-09-9 结构式

基本信息物理化学性质安全数据 N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺价格(试剂级) 常见问题列表

基本信息

中文别名

N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺

英文别名

FPL 62064
N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine
1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-

物理化学性质

沸点442.6±25.0 °C(Predicted)

密度1.15±0.1 g/cm3(Predicted)

储存条件Keep in dark place,Sealed in dry,Room Temperature

溶解度DMSO: 250 mg/mL (942.29 mM)

酸度系数(pKa)2.42±0.50(Predicted)

形态Solid

颜色Light yellow to yellow

安全数据

危险性符号(GHS)

GHS08

警示词警告

危险性描述H341

防范说明P501-P202-P201-P280-P308+P313-P405

N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-105024	N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 FPL 62064	103141-09-9	5mg	1500元
2024/04/30	S0759	N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 FPL 62064	103141-09-9	5mg	1570.85元
2024/04/30	HY-105024	N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 FPL 62064	103141-09-9	10mM * 1mLin DMSO	1666元

常见问题列表

生物活性

FPL 62064 是一种 5-lipoxygenase (5-LOX) 和 prostaglandin synthetase (cyclooxygenase, COX) 的有效双重抑制剂，对RBL-1胞质5-LOX和精囊prostaglandin synthetase的IC50值分别为3.5 μM和3.1 μM。FPL 62064 具有有效的抗炎活性。

靶点

Target	Value
seminal vesicle prostaglandin synthetase (Cell-free assay)	3.1 μM
RBL-1 cytosolic 5-LOX (Cell-free assay)	3.5 μM

体外研究

FPL 62064 inhibits both 5-1ipoxygenase (IC ₅₀ of 3.5 μM for RBL-1 cytosolic 5-1ipoxygenase) and prostaglandin synthetase (IC ₅₀ of 3.1 μM for seminal vesicle prostaglandin synthetase ) with equal facility in the isolated enzyme screens. However in the intact RBL-I cell prostaglandin synthetase (IC ₅₀ of 3.6 μM) is more readily inhibited by FPL 62064 than is 5-1ipoxygenase (IC ₅₀ of 31 μM). This difference in sensitivity is not reflected in the mouse macrophage where the IC ₅₀ s for leukotriene (IC ₅₀ of 0.72 μM) and prostaglandin (IC ₅₀ of 0.43 μM) production are similar.

体内研究

FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex.

Animal Model:	Female LACA mice (20-30 g) injected with immune complex.
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection
Result:	Produced a dose-related inhibition of dye extravasation, leukotriene C ₄ (LTC ₄ ) and prostaglandin E ₂ (PGE ₂ ) formation.