105637-50-1
中文名称
ML-9盐酸盐
英文名称
ML-9 HYDROCHLORIDE
CAS
105637-50-1
分子式
C15H18Cl2N2O2S
分子量
361.29
MOL 文件
105637-50-1.mol
更新日期
2024/09/27 11:45:51
105637-50-1 结构式
基本信息
中文别名
ML-9盐酸盐1-(5-氯萘磺酰基)-1H-六氢-1,4-二氮杂卓, 盐酸盐
1-(5-氯萘-1-磺酰基)-1H-六氢-1,4-二吖庚因盐酸盐
英文别名
ML-9ML-9, HCl
ML-9 HYDROCHLORIDE
1-(5-CHLORONAPHTHALENE- SULFONYL)HOMOPIPERAZINE
1-(5-chloronaphthalene-1-sulfonyl)-1H-*hexahydro-
1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HE XAHYDRO-1,
1-(5-CHLORONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL
1-(chloronaphthalenesulfonyl)-1H-hexahydrodiazepine HCl
1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE
1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE
常见问题列表
生物活性
ML-9 HCl (ML-9 hydrochloride) 是一种有效的选择性的 Akt kinase、myosin light chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制剂。ML-9 HCl 是一种靶向自噬和细胞死亡的亲溶酶体剂。靶点
| Target | Value |
|
Akt
() | |
|
MLCK
() | |
|
STIM1
() | |
|
Ca2+-permeable channels
() |
体外研究
ML9 (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death. ML9 (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%.
Cell Viability Assay
| Cell Line: | Neonatal rat ventricular myocytes (NRVM) cells |
| Concentration: | 0, 10, 50 and 100 μM |
| Incubation Time: | 0, 1, 4, 8 and 24 hours |
| Result: | Decreased cell viability at 50-100 μM concentration. |
Apoptosis Analysis
| Cell Line: | Neonatal rat ventricular myocytes (NRVM) cells |
| Concentration: | 50 μM |
| Incubation Time: | 1, 4 and 8 hours |
| Result: | Induced cardiomyocyte death through necrosis and apoptosis. |