107097-80-3
中文名称
氯谷胺
英文名称
LOXIGLUMIDE
CAS
107097-80-3
分子式
C21H30Cl2N2O5
分子量
461.38
MOL 文件
107097-80-3.mol
更新日期
2024/08/02 14:00:33
107097-80-3 结构式
基本信息
中文别名
氯谷胺氯谷胺, >98%
英文别名
CS-162cr1505
anoicacid
(+-)--5-oxo
LOXIGLUMIDE
ntanoicacid
Loxiglumide, >98%
LoxigluMide (CR1505)
Loxiglumide >=97% (HPLC)
(+-)-4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxope
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点113-115℃
沸点632.2±55.0 °C(Predicted)
密度1.233±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度二甲基亚砜：≥5mg/mL
酸度系数(pKa)pKa ~5(at 25℃)
形态粉末
颜色白色至米色
CAS 数据库107097-80-3
常见问题列表
生物活性
Loxiglumide 是缩胆囊素 (CCK-1) 受体拮抗剂。靶点
CCK-1 receptor
体内研究
The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest).