108409-83-2
108409-83-2 结构式
基本信息
FH535, 一种WNT/Β-CATENIN和PPAR信号传导抑制剂
WNT/BETA-CATENIN和PPAR信号通路抑制剂(FH535)
CS-1433
FH 535(FH-535)
FH 535 USP/EP/BP
FH535
FH 535
FH-535
β-Catenin/Tcf Inhibitor, FH535
2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide
N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide
Benzenesulfonamide, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-
β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
物理化学性质
常见问题列表
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PPAR
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Wnt
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β-catenin
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FH535 is an inhibitor of Wnt/β-catenin and PPAR. FH535 inhibits PPARγ and PPARδ transactivation in HCT116 cells. FH535 (15 μM) activities depend on functional PPARδ but does not require a cysteine residue in the PPAR ligand-binding domain. FH535 inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows toxic effects on 12 carcinoma cell lines expressing wnt/β-catenin pathway. FH535 (20 μM) suppresses the β-catenin pathway in pancreatic cancer cells, and inhibits pancreatic cancer cell migration. Furthermore, FH535 (20, 40 μM) inhibits pancreatic cancer cell invasion and cell growth. FH535 represses angiogenesis-related genes in pancreatic cancer cells.
FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.