1094048-77-7
中文名称
I-OME-AG 538
英文名称
I-OME-AG 538
CAS
1094048-77-7
分子式
C17H12INO5
分子量
437.19
MOL 文件
1094048-77-7.mol
1094048-77-7 结构式
基本信息
中文别名
化合物 T11593 英文别名
I-OME-AG 538TYRPHOSTIN I-OME-AG 538
I-OME-TYRPHOSTIN AG 538
α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone
ALPHA-CYANO-(3-METHOXY-4-HYDROXY-5-IODOCINNAMOYL)-(3',4'-DIHYDROXYPHENYL)KETONE
I-OMe-AG 538, α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3μ,4μ-dihydroxyphenyl)ketone
常见问题列表
生物活性
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) 是 IGF-1R 激酶的特异性抑制剂。I-OMe-Tyrphostin AG 538 抑制 IGF-1R 介导的信号传导，并优先对营养缺乏的 PANC1 细胞产生细胞毒性。I-OMe-Tyrphostin AG 538 是具有 ATP 竞争性的 PI5P4Kα抑制剂，IC50 为 1 μM。靶点
IC50: 1 µM (PI5P4Kα)
体外研究
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium.
I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk.
Cell Viability Assay
| Cell Line: | PANC-1 cells |
| Concentration: | 0.1, 1, 10, 1000 µM |
| Incubation Time: | 24 hours |
| Result: | Cytotoxic to PANC-1 cells in nutrient-deprived medium. |
Western Blot Analysis
| Cell Line: | PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) |
| Concentration: | 0.03, 0.3, 3 µM |
| Incubation Time: | 1 hour |
| Result: | Blocked phosphorylation of IGF-1R, Akt and Erk. |