110221-44-8
中文名称
盐酸替莫普利
英文名称
Temocapril hydrochloride
CAS
110221-44-8
分子式
C23H28N2O5S2.HCl
MDL 编号
MFCD00933433
分子量
513.07
MOL 文件
110221-44-8.mol
更新日期
2024/07/15 17:10:59
110221-44-8 结构式
基本信息
中文别名
[(2S,6R)-6-[[(S)-1-(乙氧羰基)-3-苯基丙基]氨基]-5-氧代-2-(2-噻吩基)-1,4-硫氮杂卓-4-基]乙酸盐酸盐替莫普利盐酸盐
盐酸替莫普利
英文别名
TEMOCAPRIL HYDROCHLORIDETemocapril Hcl
TemocarpileHCL
Temocarpilhydrochloride
(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride
Acecol
CS-622
1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI)
1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-
(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride
(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride
2-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)-2,5,6,7-tetrahydro-1,4-thiazepine-4(3H)-yl]acetic acid·hydrochloride
所属类别
生物化工:RAAS 抑制剂物理化学性质
熔点196-2000C (dec)
比旋光度25D +47.7° (c = 1 in DMF)
储存条件-20°C冷冻
溶解度DMF(微溶)、DMSO(微溶)、甲醇(微溶)
形态固体
颜色白色至灰白色
盐酸替莫普利价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-B0384 | 盐酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 5 mg | 304元 |
2024/08/19 | HY-B0384 | 盐酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 10mM * 1mLin DMSO | 343元 |
2024/08/19 | HY-B0384 | 盐酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 10mg | 480元 |
常见问题列表
生物活性
Temocapril HCl (CS-622)是Temocapril的盐酸盐形式,是一种长效的血管紧张素转换酶(ACE)抑制剂,用于治疗高血压。靶点
Target | Value |
ACE |
体外研究
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver.
体内研究
Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.
Animal Model: | Male Sprague Dawley rats |
Dosage: | 30 mg/kg |
Administration: | Oral administration, daily, for 4 weeks |
Result: | Suppressed the blood pressure elevation induced by Ang I. |