1165923-54-5

中文名称 2(1H)-Isoquinolinepropanoic acid,6-[5-[3-cyano-4-(1-Methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-3,4-dihydro-5-Methyl-,sodiuM salt(1:1)

英文名称 2(1H)-Isoquinolinepropanoic acid,6-[5-[3-cyano-4-(1-Methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-3,4-dihydro-5-Methyl-,sodiuM salt(1:1)

CAS 1165923-54-5

分子式 C25H27N4NaO4

分子量 470.5

MOL 文件 1165923-54-5.mol

1165923-54-5 结构式

基本信息应用领域

基本信息

中文别名

化合物 T32006

英文别名

GSK2262167
GSK-2262167
GSK 2262167
GSK-2262167 sodium
LCIDCFMLDWPFGR-UHFFFAOYSA-N
2(1H)-Isoquinolinepropanoic acid,6-[5-[3-cyano-4-(1-Methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-3,4-dihydro-5-Methyl-,sodiuM salt(1:1)

应用领域

用途一

GSK-2262167 is a potent S1P3-sparing and orally active S1P1 agonist. CGSK-2262167 is as efficacious as fingolimod in a collagen-induced arthritis model and shows excellent pharmacokinetic properties preclinically. Importantly, the selectivity of GSK-2262167 against S1P3 is responsible for an absence of cardiovascular signal in telemetered rats, even at high dose levels.