119615-63-3
中文名称
盐酸奥普力农
英文名称
OLPRINONE HYDROCHLORIDE
CAS
119615-63-3
分子式
C14H10N4O.ClH.H2O
分子量
304.736
MOL 文件
119615-63-3.mol
更新日期
2024/07/19 08:41:35
119615-63-3 结构式
基本信息
中文别名
盐酸奥普力农化合物 T5033L
1,2-二氢-5-咪唑并[...
英文别名
e1020Coretec
OLPRINONE HCL
xo-,monohydrochloride,monohydrate
3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o
1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride
3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
所属类别
有机原料：羧酸类化合物及衍生物
常见问题列表
生物活性
Olprinone (Loprinone) Hydrochloride 是一种有效的磷酸二酯酶 (PDE) 3 抑制剂，对 PDE1，PDE2，PDE3，PDE4 的 IC50 分别为 150、100、0.35 和 14 μM。Olprinone Hydrochloride 因其正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。体内研究
Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats.
| Animal Model: | Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats) |
| Dosage: | 0.2 mg/kg |
| Administration: | I.p. (administered 15 min after ischemia) |
| Result: | Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL). |