1196504-54-7
中文名称
GDC0575 HYDROCHLORIDE
英文名称
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
CAS
1196504-54-7
分子式
C16H21BrClN5O
分子量
414.73
MOL 文件
1196504-54-7.mol
1196504-54-7 结构式
基本信息
中文别名
化合物GDC0575 MONOHYDROCHLORIDE 英文别名
EOS-62352GDC0575 hydrochloride
GDC0575 monohydrochloride
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
应用领域
用途一
GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.