1355228-38-4
1355228-38-4 结构式
基本信息
英文别名
K8113-Quinolinecarboxamide, N-[4-[(6,7-dimethoxy-4-cinnolinyl)oxy]phenyl]-1,4-dihydro-1-(1-methylethyl)-4-oxo-
应用领域
用途一
K811 is an ASK1-specific inhibitor that prolongs survival in a mouse model of amyotrophic lateral sclerosis. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpressing GC cells. Treatment with K811 reduced sizes of xenograft tumors by downregulating proliferation markers.