13553-79-2
![13553-79-2 结构式](/CAS/GIF/13553-79-2.gif)
基本信息
利福霉素S
利福平霉素
利福霉素 S
利福霉素-D4
98%利福霉素S
利福霉素钠EP杂质E
利福霉素S EP标准品
利福昔明杂质E (EP/BP)
98%纯度利福霉素S原料(科研)
rifamycin
nci144-130
rifomycins
RIFAMYCIN S
RIFAMPICIN S
Rifamycin S CRS
Rifamycin S USP/EP/BP
Rifamycin EP Impurity B
Rifaximin EP Impurity E
物理化学性质
安全数据
常见问题列表
日前,由中国科学院青岛生物能源与过程研究所研究员李盛英带领的酶工程研究组,与中科院上海生命科学研究院植物生理生态研究所赵国屏和肖友利研究组,以及中科院上海有机化学研究所唐功利团队的多名学者合作,在国际上首次阐明了利福霉素SV转化为利福霉素B的详细生物合成途径及酶催化反应机制,相关成果已在线发表于最新出版的《自然-通讯》(Nature Communications)期刊上。
Gram-positive bacteria
Reactive oxygen species (ROS)
The inhibition of bacterial growth by Rifamycin SV is due to the production of active species of oxygen resulting from the oxidation-reduction cycle of Rifamycin SV in the cells. The aerobic oxidation of Rifamycin SV to Rifamycin S is induced by metal ions, such as Mn 2+ , Cu 2+ , and Co 2+ . The most effective metal ion is Mn 2+ .
Rat liver sub-mitochondrial particles also generated hydroxyl radical in the presence of NADH and Rifamycin S. NADH dehydrogenase (complex I) as the major component involved in the reduction of Rifamycin S. Compared to NADPH, NADH is almost as effective (Rifamycin S) in catalyzing the interactions of these antibiotics with rat liver microsomes. Rifamycin S is shown to be readily reduced to Rifamycin SV, the corresponding hydroquinone by Fe(II). Rifamycin S forms a detectable Fe(II)-(Rifamycin S)3 complex. The Fe:ATP induced lipid peroxidation is completely inhibited by Rifamycin S. Rifamycin S can interact with rat liver microsomes to undergo redox-cycling, with the subsequent production of hydroxyl radicals when iron complexes are present.