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13558-31-1

中文名称 罗丹明
英文名称 RHODAMINE 110
CAS 13558-31-1
EINECS 编号 236-944-7
分子式 C20H15ClN2O3
MDL 编号 MFCD00042009
分子量 366.8
MOL 文件 13558-31-1.mol
更新日期 2024/10/23 10:56:49
13558-31-1 结构式 13558-31-1 结构式

基本信息

中文别名
罗丹明
罗丹明560
氯化罗丹明 110
罗明丹110
英文别名
O-(6-AMINO-3-IMINO-3H-XANTHEN-9-YL)BENZOIC ACID HYDROCHLORIDE
R110
RHODAMIN 110 CHLORIDE
RHODAMINE 110
RHODAMINE 110 CHLORIDE
RHODAMINE 560
RHODAMINE HYDROCHLORIDE
3,6-diamino-9-(2-carboxyphenyl)xanthylium chloride
RHODAMINE 110 CHLORIDE, FOR FLUOR-ESCENC E
Rhodamine 110, laser grade, pure, 99%
2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid hydrochloride
Exciton Rhodamine 560 Chloride
Rhodamin 110
Rhodamine 110, 99%, laser grade, pure
3,6-Diamino-9-(2-carboxyphenyl)xanthylium
所属类别
染料及颜料:碱性染料

物理化学性质

熔点>300 °C(lit.)
密度1.2504 (rough estimate)
折射率1.6470 (estimate)
储存条件Keep in dark place,Inert atmosphere,Room temperature
溶解度可溶于乙醇
形态结晶粉末
颜色白色至浅黄色
最大波长(λmax)499nm (MeOH); 496nm (H2O)
BRN4631860
稳定性有吸湿性、光敏性
生物领域应用Detecting risk of Alzheimer’s disease and stroke;evaluating/testing sperm quality; identifying bacteria; as a substrate for measuring aromatase activity, azoreductase activity,phospholipase activity, proteases activity (caspase activity, cathepsin C activity, elastase activity proteinase activity);implantable drug-delivery devices
主要应用Color filters; liquid crystal displays; dye lasers;electroluminescent displays;inks;light-emitting diode (LED);papermaking process; recording materials; solar cells; silica thin films;sol–gel titania films;waveguides

安全数据

危险性符号(GHS)GHS hazard pictograms
GHS07
警示词警告
危险性描述H302
防范说明P301+P312
危险品标志Xn
危险类别码22
安全说明22-24/25
WGK Germany3
海关编码29329990

应用领域

用途1
激光染料。

常见问题列表

吸收及优点
罗丹明类探针的优点是内酰胺环打破了氧杂蒽的π共轭,导致极低的吸收和荧光背景;在分析物的作用下,开环后可以恢复罗丹明的颜色和荧光,实现高信号/背景比分析。但是衍生物开环后通常在500 ~ 550 nm处出现最大吸收峰,在520 ~ 580 nm处发出荧光,这对于生物成像来说波长相对较短。
生物活性
Rhodamine 110 是一种灵敏和选择性的底物 (substrate),用于测定溶液或活细胞内的蛋白酶。激发波长为 498 nm,发射波长为 521 nm。
体外研究

Rhodamine 110 accumulates in mitochondria in a cationic form, which alters the pH in this cellular compartment. Rhodamine 110 accumulates in human lymphoblastoid cells and Friend leukemia cells. No cytotoxicity to human lymphoblastoid cells is observed below 10 μM, but Rhodamine 110 causes Friend leukemia cells to die at a concentrations above 100 μM.

体内研究

Rhodamine 110 is less toxic than the parent molecule based on the intravenous LD 50 acute toxicity values of 89.5 mg/kg and 140.0 mg/kg for Rhodamine B and Rhodamine 110, respectively. Both molecules induce liver and kidney enlargement after ingestion, and male rats show more significant increases than female rats after Rhodamine 110 exposure. In addition, testis weight increased in male rats dosed with Rhodamine 110. The pharmacokinetics of Rhodamine 110 are assessed following oral administration at two dosages (3 and 10 mg/kg) and intravenous administration at one dosage (3 mg/kg). Pharmacokinetic parameters are calculated using an extravascular input and IV-bolus input, noncompartmental model analysis conducted with WinNonlin Standard Edition. The pharmacokinetic parameters of Rhodamine 110 indicates that the maximum plasma concentrations (C max ) of the two oral dosages are 283.4 and 657.0 ng/mL, which are reached at 140 and 210 min, respectively. This indicates that Rhodamine 110 absorption is not rapid after ingestion, as it took over 2 h to be absorbed from the intestines into the blood. The areas under the concentration–time curves (AUCs) for the two dosages are 138.1±20.3 and 444.0±170.8 h ng/mL. The pharmacokinetic data demonstrate that the AUC is proportional to the administered oral dose of Rhodamine 110 (3 mg/kg and 10 mg/kg). Furthermore, the clearance (Cl) of the two orally administered doses is 7.94 and 8.61 mL/min/kg, respectively.

罗丹明价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/08/1941907罗丹明110(99%)
Rhodamine 110, 98+%, pure, laser grade
13558-31-1500mg2707元
2024/08/1941907罗丹明110(99%)
Rhodamine 110, 98+%, pure, laser grade
13558-31-12.5g8333元
2024/08/19HY-D0817罗丹明
Rhodamine 110
13558-31-150mg500元
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