146669-29-6
中文名称
(+/-)MCPG
英文名称
(RS)-MCPG
CAS
146669-29-6
分子式
C10H11NO4
MDL 编号
MFCD00210205
分子量
209.2
MOL 文件
146669-29-6.mol
146669-29-6 结构式
基本信息
中文别名
(+/-)MCPG 英文别名
(+/-)-ALPHA-METHYL-(4-CARBOXYPHENYL)GLYCINE[+/-]-MCPG
(RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
(RS)-A-METHYL-4-CARBOXYPHENYLGLYCINE
(RS)-MCPG
(+/-)MCPG
(+/-)-A-METHYL-(4-CARBOXYPHENYL)GLYCINE
(+-)-A-METHYL-4-CARBOXYPHENYLGLYCINE MET ABOTROPIC GLUTAMAT
所属类别
生物化工：甘氨酸类衍生物物理化学性质
沸点425.3±40.0 °C(Predicted)
密度1.390±0.06 g/cm3(Predicted)
储存条件Keep in dark place,Inert atmosphere,Room temperature
溶解度DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming)
酸度系数(pKa)1.76±0.10(Predicted)
形态粉末
颜色白色
常见问题列表
生物活性
(RS)-MCPG (alpha-MCPG) 是一种竞争性和选择性 I/II 组代谢型谷氨酸受体 (mGluR) 拮抗剂。(RS)-MCPG 阻断 TBS 诱导的幼年和新生大鼠海马神经元的转变。靶点
group I/group II mGluR
体外研究
MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3).
体内研究
(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons.
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent.