154927-31-8

中文名称 ZK118182 isopropyl ester

英文名称 ZK118182 isopropyl ester

CAS 154927-31-8

分子式 C23H37ClO5

分子量 428.99

MOL 文件 154927-31-8.mol

154927-31-8 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 T29225

英文别名

ZK118182 isopropyl ester
QLJUNFBXIBNQOL-LMJZMJOFSA-N
ZK118182 isopropyl ester Exclusive
propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate
Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI)

物理化学性质

储存条件-20°C储存

溶解度DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml

应用领域

用途一

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF_2α and PGD₂, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC₅₀ = 16.5 nM) and a high nanomolar affinity for the DP receptor (K_i = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.